EXPEDITED ARTICLES
|
407-412
| Identification and Initial Structure-Activity Relationships of (R)-5-(2-Azetidinylmethoxy)-2-chloropyridine (ABT-594), a Potent, Orally Active, Non-Opiate Analgesic Agent Acting via Neuronal Nicotinic Acetylcholine Receptors
Mark W. Holladay,
James T. Wasicak,
Nan-Horng Lin,
Yun He,
Keith B. Ryther,
Anthony W. Bannon,
Michael J. Buckley,
David J. B. Kim,
Michael W. Decker,
David J. Anderson,
Jeffrey E. Campbell,
Theresa A. Kuntzweiler,
Diana L. Donnelly-Roberts,
Marietta Piattoni-Kaplan,
Clark A. Briggs,
Michael Williams, and
Stephen P. Arneric
[Full Article -
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413-419
| 2-Chloro-4-(trifluoromethyl)pyrimidine-5-N-(3',5'-bis(trifluoromethyl)phenyl)- carboxamide: A Potent Inhibitor of NF- B- and AP-1-Mediated Gene Expression Identified Using Solution-Phase Combinatorial Chemistry
Robert W. Sullivan,
Colin G. Bigam,
Paul E. Erdman,
Moorthy S. S. Palanki,
David W. Anderson,
Mark E. Goldman,
Lynn J. Ransone, and
Mark J. Suto
[Full Article -
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ARTICLES
|
420-427
| Design, Synthesis, and Biological Evaluation of Conformationally Constrained aci-Reductone Mimics of Arachidonic Acid
Allen T. Hopper,
Donald T. Witiak, and
John Ziemniak
[Full Article -
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428-436
| Specificity of Diastereomers of [99mTc]TRODAT-1 as Dopamine Transporter Imaging Agents
Sanath K. Meegalla,
Karl Plössl,
Mei-Ping Kung,
D. Andrew Stevenson,
Mu Mu,
Steven Kushner,
Louise M. Liable-Sands,
Arnold L. Rheingold, and
Hank F. Kung
[Full Article -
PDF] |
437-450
| Identification and Initial Structure-Activity Relationships of a Novel Class of Nonpeptide Inhibitors of Blood Coagulation Factor Xa
Scott I. Klein,
Mark Czekaj,
Charles J. Gardner,
Kevin R. Guertin,
Daniel L. Cheney,
Alfred P. Spada,
Scott A. Bolton,
Karen Brown,
Dennis Colussi,
Christopher L. Heran,
Suzanne R. Morgan,
Robert J. Leadley,
Christopher T. Dunwiddie,
Mark H. Perrone, and
Valeria Chu
[Full Article -
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451-467
| Mapping the Melatonin Receptor. 5. Melatonin Agonists and Antagonists Derived from Tetrahydrocyclopent[b]indoles, Tetrahydrocarbazoles and Hexahydrocyclohept[b]indoles
David J. Davies,
Peter J. Garratt,
Derek A. Tocher, and
Stefan Vonhoff
, John Davies
, Muy-Teck Teh and
David Sugden
[Full Article -
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468-477
| Rigid Phencyclidine Analogues. Binding to the Phencyclidine and 1 Receptors
Robert M. Moriarty,
Livia A. Enache,
Lei Zhao,
Richard Gilardi,
Mariena V. Mattson, and
Om Prakash
[Full Article -
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478-488
| Random or Rational Design? Evaluation of Diverse Compound Subsets from Chemical Structure Databases
Thorsten Pötter and
Hans Matter
[Full Article -
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489-502
| Novel Non-Peptide Fibrinogen Receptor Antagonists. 1. Synthesis and Glycoprotein IIb-IIIa Antagonistic Activities of 1,3,4-Trisubstituted 2-Oxopiperazine Derivatives Incorporating Side-Chain Functions of the RGDF Peptide
Hirosada Sugihara,
Hideto Fukushi,
Toshio Miyawaki,
Yumi Imai,
Zen-ichi Terashita,
Masaki Kawamura,
Yukio Fujisawa, and
Shunbun Kita
[Full Article -
PDF] |
503-508
| Inhibition of Human O6-Alkylguanine-DNA Alkyltransferase and Potentiation of the Cytotoxicity of Chloroethylnitrosourea by 4(6)-(Benzyloxy)-2,6(4)-diamino-5-(nitro or nitroso)pyrimidine Derivatives and Analogues
Isamu Terashima and
Kohfuku Kohda
[Full Article -
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509-514
| Synthesis and Calcium Channel-Modulating Effects of Alkyl (or Cycloalkyl) 1,4-Dihydro-2,6-dimethyl-3-nitro-4-pyridyl-5-pyridinecarboxylate Racemates and Enantiomers
Manian Ramesh,
Wandikayi C. Matowe,
Murthy R. Akula,
Dean Vo,
Lina Dagnino,
Moy Cheong Li-Kwong-Ken,
Michael W. Wolowyk, and
Edward E. Knaus
[Full Article -
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515-529
| The Partitioning of Phosphoramide Mustard and Its Aziridinium Ions among Alkylation and P-N Bond Hydrolysis Reactions
Ellen M. Shulman-Roskes,
Dennis A. Noe,
Michael P. Gamcsik,
Allison L. Marlow,
John Hilton,
Frederick H. Hausheer,
O. Michael Colvin, and
Susan M. Ludeman
[Full Article -
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530-539
| N-{trans-2-[[2'-(Acetylamino)cyclohexyl]oxy]acetyl}-L-alanyl-D-glutamic Acid: A Novel Immunologically Active Carbocyclic Muramyl Dipeptide Analogue
Danijel Kikelj,
Slavko Pe ar,
Vladimir Kotnik,
Anton talc,
Branka Wraber-Herzog,
Sa a Sim i ,
Alojz Ihan,
Lidija Klamfer,
Lu ka Pov i ,
Rok Grahek,
Elizabeta Suhadolc,
Mirjam Ho evar,
Helmut Hönig, and
Renate Rogi-Kohlenprath
[Full Article -
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540-554
| 29-Methylidene-2,3-oxidosqualene Derivatives as Stereospecific Mechanism-Based Inhibitors of Liver and Yeast Oxidosqualene Cyclase
Maurizio Ceruti,
Flavio Rocco,
Franca Viola,
Gianni Balliano,
Paola Milla,
Silvia Arpicco, and
Luigi Cattel
[Full Article -
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555-563
| A1 Adenosine Receptor Antagonists as Ligands for Positron Emission Tomography (PET) and Single-Photon Emission Tomography (SPET)
Marcus H. Holschbach,
Thomas Fein,
Christof Krummeich,
Robert G. Lewis,
Walter Wutz,
Ulrich Schwabe,
Dieter Unterlugauer, and
Ray A. Olsson
[Full Article -
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564-578
| A Novel Class of Orally Active Non-Peptide Bradykinin B2 Receptor Antagonists. 1. Construction of the Basic Framework
Yoshito Abe,
Hiroshi Kayakiri,
Shigeki Satoh,
Takayuki Inoue,
Yuki Sawada,
Keisuke Imai,
Noriaki Inamura,
Masayuki Asano,
Chie Hatori,
Akira Katayama,
Teruo Oku, and
Hirokazu Tanaka
[Full Article -
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579-590
| Synthesis and Anticonvulsant Activity of a New Class of 2-[(Arylalkyl)amino]alkanamide Derivatives
Paolo Pevarello,
Alberto Bonsignori,
Philippe Dostert,
Franco Heidempergher,
Vittorio Pinciroli,
Maristella Colombo,
Robert A. McArthur,
Patricia Salvati,
Claes Post,
Ruggero G. Fariello, and
Mario Varasi
[Full Article -
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591-601
| Asymmetric Synthesis and Pharmacology of Methylphenidate and Its Para-Substituted Derivatives
Dung L. Thai,
Michael T. Sapko,
Clara T. Reiter,
Donald E. Bierer, and
James M. Perel
[Full Article -
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602-617
| Discovery of Ritonavir, a Potent Inhibitor of HIV Protease with High Oral Bioavailability and Clinical Efficacy
Dale J. Kempf,
Hing L. Sham,
Kennan C. Marsh,
Charles A. Flentge,
David Betebenner,
Brian E. Green,
Edith McDonald,
Sudthida Vasavanonda,
Ayda Saldivar,
Norman E. Wideburg,
Warren M. Kati,
Lisa Ruiz,
Chen Zhao,
LynnMarie Fino,
Jean Patterson,
Akhteruzzaman Molla,
Jacob J. Plattner, and
Daniel W. Norbeck
[Full Article -
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618-622
| Synthesis of a Methylenebis(phosphonate) Analogue of Mycophenolic Adenine Dinucleotide: A Glucuronidation-Resistant MAD Analogue of NAD
Krystyna Lesiak,
Kyoichi A. Watanabe,
Alokes Majumdar,
James Powell,
Michael Seidman,
Kristen Vanderveen,
Barry M. Goldstein, and
Krzysztof W. Pankiewicz
[Full Article -
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623-639
| Synthesis and Biological Activity of a Novel Series of Nonsteroidal, Peripherally Selective Androgen Receptor Antagonists Derived from 1,2-Dihydropyridono[5,6-g]quinolines
Lawrence G. Hamann,
Robert I. Higuchi,
Lin Zhi,
James P. Edwards,
Xiao-Ning Wang,
Keith B. Marschke,
James W. Kong,
Luc J. Farmer and
Todd K. Jones
[Full Article -
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640-649
| Highly Selective and Orally Active Inhibitors of Type IV Collagenase (MMP-9 and MMP-2): N-Sulfonylamino Acid Derivatives
Yoshinori Tamura,
Fumihiko Watanabe,
Takuji Nakatani,
Ken Yasui,
Masahiro Fuji,
Tadafumi Komurasaki,
Hiroshige Tsuzuki,
Ryuji Maekawa,
Takayuki Yoshioka,
Kenji Kawada,
Kenji Sugita, and
Mitsuaki Ohtani
[Full Article -
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NOTES
|
650-652
| Effects of - and -Galactosylated C2-Ceramides on the Immune System
Teruyuki Sakai,
Hitomi Ueno,
Takenori Natori,
Akira Uchimura,
Kazuhiro Motoki, and
Yasuhiko Koezuka
[Full Article - PDF] |
BOOK REVIEWS
|
653-653
| Recent Developments in Theoretical Studies of Proteins Edited by Ron Elber. World Scientific Publishing Co. Pte. Ltd., Singapore. 1996. viii + 399 pp. 16 × 22 cm. ISBN 981-02-2196-7. $78.00.
Donald J. Kyle
[Full Article - PDF] |
653-654
| ACCORD Synopsys Scientific Systems Ltd., United Kingdom. Version 2.0 for Windows. 495 ( 295 academic price).
Richard A. Glennon, Ph.D.
[Full Article - PDF] |
654-654
| HPLC Methods for Pharmaceutical Analysis By George Lunn and Norman R. Schmuff. John Wiley and Sons, Inc., New York. 1997. xxii + 1609 pp. 19 × 26 cm. ISBN 0-471-18176-5. $150.00.
John F. Fitzloff
[Full Article - PDF] |